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Systematic validation of specific phenotypic markers for in vitro polarized human macrophages

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Manifestations of hepatic oxidative damage include dysregulation of lipid metabolism (leading to steatosis), hepatocyte degeneration and death, and activated immune response (leading to inflammation and fibrosis/cirrhosis)

The trade-off is a very short half-life of approximately 20-30 minutes after subcutaneous injection, making it unsuitable for systemic use and largely studied in local tissue applications [10]