The MCC is one of three approaches that Mtb can use to metabolise the potentially toxic propionyl-CoA that is derived from the catabolism of host-derived sterols, odd-chain fatty acids and branched-chain amino acids, substrates that are present and utilised in vivo (Lee et al, 2013)
Feng H, Schorpp K, Jin J, Yozwiak CE, Hoffstrom BG, Decker AM, et al
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Most protocols hold each dose level for at least 4 weeks before escalating
Oxidative stress disrupts the integrity of the BBB through mechanisms that result from an excess of reactive oxygen species (ROS) accompanied by a compromised intrinsic antioxidant defense [81]
You can also encounter rare, serious side effects like: Its important to call your doc ASAP if you notice any of these negative effects