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Carefully controlled, longitudinal studies that integrate epitranscriptomic profiling with metabolite, cytokine, and vascular phenotyping will be critical to translate these mechanistic insights into durable immuno-vascular therapies (120, 121)

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Packer M et al., SUMMIT, NEJM 2024 (NEJMoa2410027, PMID 39555826) : tirzepatide and HFpEF with obesity, HR 0,62 composite endpoint

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