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Still, no interaction in terms of effectiveness and safety by reduced eGFR or diabetes status was observed in the original COMPASS trial,129 but there was a tendency to a lower benefit in patients with diabetes, as well as a higher risk of bleeding among patients with diabetes and patients with reduced eGFR in the VOYAGER PAD trial.128 Furthermore, patients with CKD stage 5 or 5D were excluded from these trials, limiting the extrapolation of the results to this subgroup of patients with diabetes and CKD

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