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Results showed that HMSeBA upregulated the protein level of GPX4 in IPEC-J2 cells, while AdshGPX4 significantly decreased the protein abundance of GPX4 compared with control group, under both basal or HMSeBA treatment conditions (Figure 5A)

The phase 3 SURMOUNT programme assessed the safety and efficacy of tirzepatide as obesity treatment and the medication has now been approved (November 2023) for chronic weight management by the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) [46, 47]