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Oxidation reactions are crucial factors in many metabolic processes
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When ASK1 was activated, DGAT2 and GPAT4 were recruited to the LD surface, whereas when ASK1 activity was inhibited, recruitment of GPAT4 to the surface of LDs was reduced
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Mechanistically, E4s primary effect was to alleviate inflammatory responses and vascular abnormalities, with relatively modest inhibitory effects on VEGF [62]