Further studies aimed at elucidating the exact mechanisms underlying RSL3-induced DNA damage are needed
Another study identified potential inhibitors through in silico screening, discovering several chemotypes that inhibited NAPRT at micromolar concentrations
Dose Concordance Time Concordance Known modulating factors Known Feedforward/Feedback loops influencing this KER Not identified References Ainsbury, E
Chamoun K, Benton CB, AlRawi A, Jacamo R, Williams P, Wang F, Zhang J, Daver NG, Garcia-Manero G, Kantarjian HM, Futreal A, Andreeff M
Stroke 53 , 22042210 (2022)
Like other NADs, researchers have focused on nanocarriers based on liposomes, chitosan, and other materials to achieve efficient delivery, laying a solid foundation for the clinical application of the CRISPR/Cas9 system