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Atorvastatin disrupts autophagy by inhibiting Rab GTPase geranylgeranylation, which is critical for lysosomal trafficking and acidification, thereby impairing degradation of damaged mitochondria [9]
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These alterations are the probable result of the lengthy cellular damage induced by MTX resulting in increased levels of ROS leading to DNA injury, oxidation, and proliferation inhibition
Metabolomics 11(5):11571174
Miller et al., 2009
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