Ensure sufficient protein, healthy fats, and micronutrients even if hunger is low
Murto T, Kallak TK, Hoas A, et al
Blood 101 , 348350 (2003)
This plays into manufacturer strategy: a company often agrees to Karls principle in the UK (cut price until NICE approves) instead of launching a drug that NICE will block
Also, the variability in follow-up duration across the included RCTs can affect event capture rates and risk estimates, as shorter trials may underreport long-term outcomes while longer trials may reflect cumulative risks
The impact of energy deprivation on the signaling pathways of erythrocytes was later disclosed in a mechanistic study: here, the authors demonstrated that removal of extracellular glucose and blockade of glycolysis by 2-deoxyglucose leads to fast depletion of cellular ATP