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In our 3D skin model comprising keratinocytes and fibroblasts, we showed that MMP-1 activity was increased with the combination of cigarette smoke and solar rays regardless of the UVA dose compared with the different controls (Fig

We confirmed that ROCK was activated in smokers and that ROCK activity was significantly correlated with FMD in smokers [85,86,87]

Since then, tobacco companies have developed and marketed various versions of the devices, from rechargeable units to disposable ones, along with thousands of kid-friendly flavors