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Furthermore, exosome-derived circTRPS1 from bladder cancer (BCa) cells could regulate intracellular ROS homeostasis and promote CD8 T cell depletion via the circTRPS1/miR141-3p/GLS1 axis [99]

(7) Solid tumors, inflammatory, and autoimmune states Marked or persistent unexplained elevation has been linked to malignancy in observational data