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This model reflects an established approach to constructing -omic clocks

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Nature 431(7009):707712 Khera H, Awasthi A, Mehan S (2019) Myocardial preconditioning potential of hedgehog activator purmorphamine (smoothened receptor agonist) against ischemia-reperfusion in deoxycortisone acetate salt-induced hypertensive rat hearts