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A balance is needed because, at high doses of 500-600 mg, caffeine can increase heart rate and shivering[9 Trusted Source 2015 - Current neuropharmacology Caffeine: Cognitive and Physical Performance Enhancer or Psychoactive Drug

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Pharmacol Rev 56(4):549580 Rissanen TT et al (2003) VEGF-D is the strongest angiogenic and lymphangiogenic effector among VEGFs delivered into skeletal muscle via adenoviruses