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Ophthalmic Indications: When applied topically as a 2.5% or 10% ophthalmic solution, phenylephrine stimulates the iris dilator muscle to produce mydriasis (pupil dilation)

GCL is specific for the glutamyl moiety and is regulated physiologically by: (a) non-allosteric feedback competitive inhibition by GSH (Ki=2.3mM), which involves binding of GSH to the glutamate and another site on the enzyme [8, 9] and (b) availability of its precursor, cysteine [1] .The apparent Km values of GCL for glutamate is 1.8 mM, and for cysteine and 0.10.3 mM [9]

10.5732/cjc.009.10274 Chin

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