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Table 1) Sleep abnormalities Individuals with PWS have sleep-disordered breathing, including central and obstructive sleep apnea, abnormal arousal, abnormal circadian rhythm in REM sleep, reduced REM latency, and abnormal response to hypercapnia 26, 27 as well as excessive daytime sleepiness

Thus, these medications deserve consideration as adjunctive therapies for psoriasis, especially in patients with metabolic comorbidities

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The 0.9% benzyl alcohol preservative inhibits bacterial growth in the reconstituted solution, allowing multiple draws from the same vial over an extended research period

Overall, the most significant results are seen over 12 years of consistent treatment, with continued benefits in longer-term follow-up