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The medical use of peptides dates back to the 1920s with the isolation of insulin, which transformed diabetes care

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Common adverse effects include nausea, vomiting, diarrhoea, constipation, and abdominal pain , particularly during the dose escalation phase (starting at 0.25 mg and gradually increasing to 2.4 mg over several weeks)

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ESWT reduces pain and inflammation, helps to realign and repair collagen fibers, promotes rehydration of synovial fluid and fascial tissues, and restores friction-free knee mechanics