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Frequently occurring skin features, apart from the skin fragility ( n = 14) and laxity/hyperextensibility ( n = 15), included soft and doughy skin texture ( n = 12), increased palmar wrinkling ( n = 6), and atrophic scarring ( n = 5)

Saleem W, Ren X, Van Den Broeck W, Nauwynck H

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Effect of pramlintide on A1C and body weight in insulin-treated African Americans and Hispanics with type 2 diabetes: a pooled post hoc analysis

They discovered that Retatrutide directly acts on these cells to decrease the secretion of ANGPTL3/8