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Higher water volumes reduce concentration but require a larger draw

The disadvantage is larger injection volumes, which some people find uncomfortable

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Therefore researchers recommend more studies are needed on how B12 may affect weight

Tesamorelin is an FDA-approved synthetic growth hormonereleasing hormone analogue that stimulates IGF-1 production to reduce visceral abdominal fat in HIV-associated lipodystrophy, though its use outside this population remains unproven