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Choose a spot in the middle third of your thigh, between the knee and the hip, focusing on the front or outer surface where subcutaneous fat is most accessible

Tirzepatide instead engineers a single peptide to activate two incretin receptors (GIP and GLP-1) at once

Avoid sugary drinks, and be mindful that caffeine may worsen gastrointestinal symptoms in some individuals

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That fatty acid chain, specifically a C20 fatty diacid, is what gives tirzepatide its extended half-life in the body

The tachyphylaxis effect also plays a role here