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10.1021/np200906s 145 NewsomeB

Phase 2 human trials of full-length Thymosin Beta-4 in pressure ulcers and venous stasis ulcers reported no significant adverse events distinguishable from placebo

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Specific differences in epinephrine concentration and norepinephrine N-methyltransferase activity in hypothalamus and brain stem

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Fourth, the study population was derived from a single geographic region (Northeast China) and recruited primarily from hospital settings, which constrains external validity and limits generalizability to broader or more diverse populations