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Tesamorelins trans-3-hexenoic acid modification at the N-terminus protects against DPP-IV cleavage, extending its effective half-life compared to native GHRH

If A1C levels remain above goal after three months of therapy, a second agent should be added (e.g., sulfonylurea, thiazolidinedione, dipeptidyl-peptidase-4 inhibitor, glucagon-like peptide-1 receptor agonist, insulin)

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It is also used concurrently with other treatments, such as chemical peels and laser treatments, to enhance results