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Authors contributions Zeynep Keskinkaya: The study concept and design, data collection, analysis and interpretation, statistical analysis, writing of the manuscript, critical review of important intellectual content, effective participation in the research guidance, intellectual participation in the propaedeutic and/or therapeutic conduct of the studied cases, critical review of the literature, final approval of the final version of the manuscript

Research has demonstrated that these reactions are highly sensitive to NAD+ availability, with studies showing that 20-30% reductions in mitochondrial NAD+ levels can decrease citric acid cycle flux by 40-60%

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