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Among 2-OGDDs, Jumonji C domain-containing histone demethylases and ten-eleven translocation (TET) family DNA demethylases are major enzymes that induce epigenetic modifications using glutamine-derived -KG
however, it did not seem to increase immune-related adverse effects or affect their safety profile [66]
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[201], patients suffering from epilepsy, frequently experienced hypoglycemia during KD initiation, with blood glucose dropping below 40 mg/dL, and six patients developed excessive ketosis with urine ketone levels of 160 mg/dL, which manifested as facial flushing
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