In sum, hepatoprotective effects of GLP1R agonist are most likely owing to stimulation of extrahepatic GLP1R function known to afford appetite suppression, reduce adiposity and improve peripheral insulin sensitivity, thereby leading to overall benefits on liver health secondary to improved features of the metabolic syndrome 85,86,87
Gut microbe-generated metabolite trimethylamine N-oxide and the risk of diabetes: A systematic review and dose-response meta-analysis
Patients should never double up on doses or take extra medication to compensate for missed doses, as this increases the risk of adverse effects without providing additional therapeutic benefit
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NAFLD during a diabetic state: therapeutic approach Lifestyle modifications (dietary changes and the implementation of healthier eating patterns (such as the Mediterranean diet), as well as increased physical activity through participation in a structured exercise program) are the cornerstones for the management of individuals with NAFLD and excess adiposity
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