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Challenges in detecting disease modification in Parkinsons disease clinical trials

Exenatide dosage is not recommended to be increased in patients with an estimated glomerular filtration rate (eGFR) of 3060 mL/min/1.73 m 2

10.1016/j.jhepr.2024.101271 33 GalassoL.CerritoL.MaccauroV.TermiteF.MigniniI.EspostoG.et al (2024)

PREGUNTAS FRECUENTES FAQS 1

The mean serum TSH level of the patients before initiation of hormone replacement therapy was recorded 66.07 57.38 mIU/L, whereas the baseline TSH level following LT 4 therapy was 3.61 4.41(mIU/L), indicating that there was as much as 18.3-fold higher level of serum TSH before treatment initiation

The discrepancy in available demographic data and the reduction in participant numbers over time may also introduce attrition bias