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Cost-effectiveness analyses consistently show that drug treatment becomes economically attractive only in patients with at least stage F2 fibrosis or with high cardiovascular risk, whereas lifestyle modification and, in particular, physical activity that induces exercise-mediated anti-inflammatory effects and dietary changes are the preferred first-line options for early, uncomplicated disease [4547]

281 Interestingly, the mechanisms by which p53 regulates glucose homeostasis involve skeletal muscles and angiogenic cells

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doi: 10.1056/NEJMoa2502081