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The peptide reduces inflammatory cytokine activity without suppressing the immune response entirely, according to a review published in the International Journal of Molecular Sciences

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In some cases, studies purport that chronically high BCAA levels can worsen insulin resistance and possibly contribute to Type 2 diabetes.3 Other studies point toward a possibility that elevated BCAA levels in pre-diabetics and those with high insulin resistance are either a byproduct of those disorders or a concurrent genetic predisposition

Interestingly, it is also common to diagnose irAEs even after the discontinuation of ICI agents