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499 It has also been observed that a ubiquitously expressed protein tyrosine phosphatase, SHP2 (Src homology-2 domain-containing protein tyrosine phosphatase-2) interacts with the transcriptional co-activators YAP/TAZ, which in turn promotes its nuclear localization

41,48,50 Reactive oxygen species (ROS) (which are generally thought to be cytotoxic molecules) produced during metabolism have been shown to amplify insulin secretion

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