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When antioxidant levels are insufficient to keep the free radicals in check, the free radicals start to damage proteins, lipids, and DNA, triggering various illnesses and health conditions, including the following: Lung diseases: Oxidative stress, such as that caused by smoking tobacco products, is related to a number of lung diseases, including asthma, chronic obstructive pulmonary disease (COPD), acute lung injury (ALI), pulmonary fibrosis, and lung cancer

doi:10.1016/S0014-5793(01)03302-6

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11.5 Pharmacokinetics and bioavailability It is evident that following oral administration, resveratrol is rapidly absorbed in the gastrointestinal tract (75%) with an extensive first-pass metabolism in the intestine and liver, lowering its oral bioavailability (ranging from 2.6 to 75% in humans and 2029% in rats fed 50 mg/kg) [198]