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New Gallup data shows that 12.4% of American adults now report using drugs like Ozempic and Wegovy for weight loss, more than double the share from early 2024 and driven largely by middle-aged adults
Carbon nanotube scaffolds tune synaptic strength in cultured neural circuits: novel frontiers in nanomaterial-tissue interactions
Phentermine A prescription stimulant that suppresses appetite and slightly boosts metabolism Often used short-term, but studies support longer use in some low-risk patients Average weight loss: ~6% Side effects: dry mouth, jitteriness, insomnia, increased heart rate Not suitable for those with heart conditions or high blood pressure Orlistat (Alli, Xenical) Blocks absorption of about 30% of dietary fat Must be taken 3x daily with meals Average weight loss: ~35% over a year Side effects: oily stools, gas, urgent bowel movements Requires a multivitamin to replace lost fat-soluble vitamins (A, D, E, K) Qsymia Combines phentermine with topiramate (originally for seizures/migraines) Targets multiple pathways: appetite + cravings Average weight loss: ~910% Side effects: dry mouth, mood changes, tingling, insomnia Women of childbearing age need reliable contraception Contrave Combines bupropion (an antidepressant) with naltrexone (used for addiction) Helps reduce emotional eating and cravings Average weight loss: ~59% Side effects: nausea, insomnia, headache, dry mouth Not for use if you have seizures, are on opioids, or have certain mental health conditions The New Era: GLP-1s, Dual, and Triple Agonists More recently, medications that target gut and brain hormones have made significant waves in obesity care
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Patients originally assigned to receive placebo were switched to glipizide 5 mg daily (titrated to 15 mg daily) for 30 weeks
Genes associated with UC were collected using the keyword ulcerative colitis from five databases: GeneCards, DrugBank, Online Mendelian Inheritance in Man (OMIM), PharmGKB, and TTD
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