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The combination of metformin and liraglutide is more effective than metformin monotherapy in improving hyperandrogenism and reproductive abnormalities.44 A meta-analysis showed that liraglutide has the strongest weight loss effect in PCOS patients compared to metformin, inositol, oseltamide, etc,45 and 510% weight loss can improve the menstrual cycle and ovulation recovery in PCOS patients.46,47 Besides, GLP-1RA can improve cardiovascular disease markers such as adiponectin in the treatment of PCOS patients, thus playing a protective role in cardiovascular disease and benefiting PCOS.30 Currently, clinical trials of GLP-1RA in PCOS are based on weight loss effects.33,34,48,49 Consistent with these results, in this study, PCOS mice showed significant weight loss after semaglutide treatment

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The current FDA status of BPC-157 is that of an unapproved drug compound with no active Investigational New Drug (IND) application accepted for human clinical trials as of available records

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One version of this hypothesis considers that the first round of WGD affected the common ancestor of all vertebrates, while the second affected the common ancestor of jawed vertebrates, after the separation from jawless vertebrates [48, 50]