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Personal or family history of medullary thyroid carcinoma (MTC): As with other GLP-1 receptor agonists, caution is advised in individuals with a history of MTC or Multiple Endocrine Neoplasia syndrome type 2, due to theoretical risk associations

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NT agonists could be a novel treatment for reducing alcohol consumption by enhancing the intoxicating effects and by possibly reducing the rewarding/reinforcing effects of alcohol