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In mice models, TMAO directly activates the NF-B pathway, prompting vascular smooth muscle cell inflammation and mitochondrial reactive oxygen species accumulation
In the adult mouse brain, scRNA-seq studies showed that IDH2 was most highly expressed in ependymal cells, astrocytes, and microglia, with lower expression in oligodendrocytes and much lower expression in neurons (Saunders et al., 2018)
55 TherkelsenKEAbrahamTMPedleyAMassaroJMSutherlandPHoffmannUet al
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Limit tension and stress as it can worsen the corticoid-induced acne rash