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Traditional clinical endpoints often lack sensitivity to detect disease-modifying effects, particularly over short trial durations

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Feng J, Li Z, Tian L, et al

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Semaglutide, tirzepatide, and retatrutide (Biosynth, Compton, UK, lot #s 0000042482, 0000054911, and 0000205204 respectively) were dissolved in 0.3% phosphate-buffered saline (PBS), which was adjusted to a pH of 8.0 using NaOH and injected subcutaneously (s.c.) at 1 ml/kg

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Recommended dosing: Subcutaneous: 200500 mcg per injection once or twice daily, rotating sites

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