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Endocrine 66 (2), 178184

C., Couper, J., Davies, J

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Josimovich JB, Lavenhar MA, Devanesan MM, Sesta HJ, Wilchins SA, Smith AC

Sequence alignments of biochemically characterized plant PPOs show that COs exclusively feature Thr as the 1 st activity controller and in most cases display Arg as the 2 nd activity controller (except for Sl PPO2, which displays Ile as the 2 nd activity controller), whereas TYRs possess a vast variety of amino acids at the 1 st and 2 nd activity controller position (Fig

Future research should build on this framework by prioritizing well-powered, longitudinal, and mechanistically integrated study designs that combine precise cycle phase verification with multi-omics approaches (e.g., metabolomics, transcriptomics, and microbiome profiling)