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P = .530)

Glucarpidase has rare and relatively mild adverse effects, including tingling, itchiness, flushing, nausea, vomiting, and headache (Green 2012)

Mitochondria, especially mitochondrial respiratory chain, has been shown to be major sources of ROS 26

HPLC can show the relative size of detected chromatographic peaks, but HPLC area percentage alone does not confirm the chemical identity or account for every possible impurity

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IR impairs mitochondrial substrate utilization, shifting energy metabolism from glucose oxidation toward fatty acid oxidation, which increases ROS production and reduces oxidative phosphorylation efficiency