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Copper ion load from AHK-Cu remains well below toxic thresholds even at 2mg daily, but chronic use beyond 6 months lacks human safety data as of 2026

Gabriel FC, Oliveira M, Martella BDM, Berk M, Brietzke E, Jacka FN, et al

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The IL-6/HO-1/STAT3 signaling pathway is implicated in the amelioration of acetaminophen-induced hepatic toxicity: A neonatal rat model

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