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Distilled of the solvent from the reaction mixture under reduced pressure and co distilled with acetonitrile

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Kidney function can slightly affect semaglutide elimination, though the kidneys role is minor since most breakdown happens through general protein degradation

About 1 in 4 patients in the study developed COVID infection

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5.3 Diabetic Retinopathy Complications In a pooled analysis of glycemic control trials with RYBELSUS, patients reported diabetic retinopathy related adverse reactions during the trial (4.2% with RYBELSUS and 3.8% with comparator) [see Adverse Reactions (6.1)]