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Currently, excessive NNMT upregulation is implicated in several scenarios, including obesity, metabolic diseases, muscle cell degeneration, and even some types of cancer [2, 4]

SOS is the most typical histological change, and is characterized by impaired sinusoidal wall integrity, sinusoidal hyperemia and blockage, sinusoidal fibrosis, fibroid blockage in the lobular central vein and nodular hyperplasia or hemacelinosis (18)

Venton BJ, Zhang H, Garris PA et al (2003) Real-time decoding of dopamine concentration changes in the caudateputamen during tonic and phasic firing