It upregulates genes involved in collagen synthesis (COL1A1, COL3A1, COL5A1), extracellular matrix remodeling (decorin, fibromodulin), and antioxidant defense (superoxide dismutase, glutathione peroxidase) while simultaneously suppressing genes associated with inflammation (IL-6, TNF-alpha), fibrinogen production, and tissue destruction (several MMPs)
Persistent high ferritin can reflect harmless inflammation, but it can also indicate serious iron overload
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28 days is the FDA requirement for producers of multi-use vials to prove their bacteriostatic maintains efficacy
I guess it depends on how low each persons individual levels are and how quickly they utilise the B12