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In rodents, ID, with or without anaemia, decreased serum T4 and T3 concentrations, lowered 5-deiodinase (DIO) activity and reduced the ability to thermoregulate in response to a cold environment ( Reference Hess, Zimmermann and Arnold 39 , Reference Beard, Tobin and Green 51 Reference Beard, Finch and Green 53 )

However, none of these studies have specifically selected children with mitochondrial dysfunction or disease to study, so it is difficult to know if individuals with ASD and mitochondrial dysfunction would benefit the most from these treatments or whether these treatments are effective for a wider group of children with ASD

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Single-cell analyses have been utilized to identify specific cell types contributing to the progression of KOA, such as anterior cruciate ligament fibroblasts [121]