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NTS GLP-1 neurons project on the lateral parabrachial nucleus (LPBN), and Ex-4 injection of LPBN neurons showed similar effects on both chow and high-fat food intake (Alhadeff et al., Expression of supramammillary nucleus (SuM) GLP-1R is comparable with the expression in the LH and NAc, but lower than that found in the NTS (Lpez-Ferreras et al., 2016)

These medications, originally developed for type 2 diabetes, work by mimicking natural gut hormones to reduce appetite and promote weight reduction

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This explains the synergy seen with semaglutide combination and positions cagrilintide as a cornerstone of next-generation medical weight loss

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