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Clinical research in people with HIV-associated abdominal fat accumulation found that tesamorelin decreased visceral adipose tissue by about 15% to 20% over 6 to 12 months

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This situation would lead to a self-perpetuating cycle, in which the free radicals generated would induce GSH depletion, thus increasing oxidative stress that would reduce antioxidant enzyme levels, which would further reduce GSH synthesis

This approval marks a significant milestone as it is the first FDA-approved activin-signaling inhibitor therapy for PAH

Francke-Carroll, S., Mohutsky, M.A., Romeike, A., Lee, W.M