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Exendin-4 treatment upregulated Sirt1 and Foxo-1 levels in the high fat diet-fed mice

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Genovese BM, Noureldine SI, Gleeson EM, Tufano RP, Kandil E

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Senolytic target engagement does not require continuous receptor binding, enzyme modulation, or persistent modulation of biochemical pathways

In doing so, researchers have been able to hypothesize that Melanotan 2 might restore or modify synaptic communication and synaptic plasticity, which may go so far as to reshape the underlying neuroarchitecture