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They are strategic choices that either align with or work against the broader healthspan objectives of the combined approach

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The Safety and Efficacy of Low-Dose Naltrexone in the Management of Chronic Pain and Inflammation in Multiple Sclerosis, Fibromyalgia, Crohn's Disease, and Other Chronic Pain Disorders

The dual mechanism is biologically significant

The balance in these MR- and GR-mediated effects on the stress system is of crucial importance to the functioning the of HPA axis