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Patients present with joint hypermobility, generalized ligamentous laxity, scoliosis, fragile skin, and cardiovascular abnormalities

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(5) Patients with significant alcohol consumption, defined as more than 20 g/day for women or 30 g/day for men, or a history of alcohol-related liver disease [18]

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LINC01133 can induce acquired ferroptosis resistance by enhancing the FSP1 mRNA stability through forming the LINC01133-FUS-FSP1 complex