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Tetrazole, a widely used heterocyclic core structure, serves as a frequent scaffold in drug design, often replacing carboxyl groups due to its resistance to metabolism

Viader, A

van Furth AM, de Heide LJM, Emous M, Veeger N, van Beek AP

Another study in the International Journal of Dermatology confirmed its role in reducing oxidative stress, a major cause of premature aging

Mitapivat was noninferior to splenectomy for amelioration of anemia and reduction in reticulocyte count (Figure 6B), and both treatments resulted in similar decreases in hemolysis biomarkers such as LDH and total bilirubin (Figure 6C)

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