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Molecules (Basel Switzerland) , 25 (3), 609

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It also prevents overfilling, which can stretch the bladder wall and worsen frequency over time

Cellular mechanisms of Decreased Response Desensitization Downregulation Tachyphylaxis Tolerance Desensitization Desensitization refers to a reduced response to an agonist drug due to over activation of a receptor (high doses, prolonged exposure to agonist)