Initially, treatment may require daily shots for two weeks to boost B12 levels
And the position of the Pernicious Anaemia Society has always been that PA is more than just B12 deficiency
Retatrutide should not be used by anyone who is pregnant, breastfeeding, or has an existing health condition
With FDA input pending, the companies are targeting a Phase 3 trial launch in the first half of 2026
While the RNI for maintenance is only 1.5 g daily, therapeutic oral doses typically range from: 50-150 g daily for mild deficiency prevention in at-risk groups 1,000-2,000 g daily for treating confirmed deficiency without malabsorption Some formulations contain up to 5,000 g, though there is no proven additional benefit over 1,000-2,000 g for most patients The reason for this dosage discrepancy lies in absorption efficiency
Pollard, J