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In contrast, GLP-1 receptor agonists approved by the FDAincluding semaglutide (Ozempic, Wegovy), dulaglutide (Trulicity), liraglutide (Victoza, Saxenda), and tirzepatide (Mounjaro, Zepbound, which also activates GIP receptors)are modified to resist DPP-4 degradation

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CT-388 GLP-1 CT-996

Impaired incretin-induced amplification of insulin secretion after glucose homeostatic dysregulation in healthy subjects

12 points placebo 6-minute walk distance: Increased 63 meters (vs

While not always listed among the core eight, GIP serves as a trigger for insulin secretion